Pseudolymphoma of the stomach

L. M. Highman, F. J. Fantelli and R. E. Hermann

Pseudolymphoma of the stomach is an unusual condition that is frequently confused with true gastric lymphoma. This has resulted in favorable long-term results in several large series of gastric lymphoma. The distinction between lymphoma and pseudolymphoma may be difficult to make on the basis of frozen sections and, occasionally, on permanent histologic sections. When the diagnosis can be made intraoperatively, a conservative procedure is indicated. When the diagnosis is suspected but cannot be made microscopically, it is suggested that observation for definite evidence of malignancy on follow-up be undertaken before initiating adjuvant therapy. This condition is frequently associated with chronic peptic ulcer disease and is considered benign. It has be proposed that pseudolymphoma, if left untreated, may progress to true lymphoma.