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Prostacyclin (Epoprostenol)Its Effect on Canine Splanchnic Blood Flow During Hemorrhagic Shock
Richard F. Seelig, MD;
John C. Kerr;
Robert W. Hobson, II, MD;
George W. Machiedo, MD
Arch Surg. 1981;116(4):428-430.
Abstract
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• Prostacyclin (epoprostenol, prostaglandin I2) is a vasodilator of the splanchnic circulation during normotensive states. To confirm the persistence of its effects after hemorrhagic shock, six anesthetized, previously splenectomized, adult mongrel dogs were subjected to hemorrhagic shock using a modified Wigger's technique in which a mean arterial pressure of 30 mm Hg was maintained until 25% of the shed blood spontaneously returned. The animals were randomly resuscitated with normal saline solution or a similar volume of saline solution containing prostacyclin. Organ blood flow was calculated by measuring the distribution of radioactively tagged microspheres. During shock, blood flows to the liver, small intestine, pancreas, and carcass were reduced. During a 60-minute infusion, prostacyclin selectively caused a significant increase in hepatic arterial blood flow. This improvement in arterial blood flow may prove beneficial in the clinical management of hemorrhagic shock.
(Arch Surg 1981;116:428-430)
Author Affiliations
From the Surgical Service, East Orange Veterans Administration Medical Center (Drs Seelig and Hobson, and Mr Kerr), East Orange, NJ, and the Department of Surgery, College of Medicine and Dentistry of New Jersey, New Jersey Medical School (Drs Seelig, Hobson, and Machiedo, and Mr Kerr), Newark.
Footnotes
Accepted for publication Dec 30, 1980.
Read at the Fourth Annual Surgical Symposium of the Association of Veterans Administration Surgeons, Alexandria, Va, May 12, 1980.
Reprint requests to Surgical Service, VA Medical Center, East Orange, NJ 07019 (Dr Seelig).
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