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Anal Cloacogenic CarcinomaClassification and Clinical Behavior
Arnold I. Serota, MD;
Mitchell Weil, MD;
Russell A. Williams, MD;
Jerome S. Wollman, MD;
Samuel E. Wilson, MD
Arch Surg. 1981;116(4):456-459.
Abstract
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• A retrospective study of 35 patients with anal cloacogenic carcinomas showed that the histological characteristics of the tumors were correlated with their biological behavior. The basaloid squamous type of cloacogenic carcinoma was more common in women (3.6:1) and had a more favorable course in both men and women, with a mean survival of 5.0 years. Glandular variants of these tumors, with an adenocystic or mucoepidermoid pattern, occurred predominantly in men and had a more aggressive course, manifested by early metastases to inguinal and mesenteric lymph nodes, liver, and lung, with mean survival limited to 2.5 years. Nine of the 11 patients who survived longer than five years had the basaloid squamous histological pattern and were treated by abdominoperineal resection or pelvic exenteration; five of these patients also received postoperative therapy with radiation. The overall actual five-year survival for patients with anal cloacogenic carcinoma was 41% in this study. The histological pattern of anal cloacogenic carcinoma provides useful prognostic information to the clinician.
(Arch Surg 1981;116;456-459)
Author Affiliations
From the Surgical (Drs Serota, Weil, Williams, and Wilson) and Pathological (Dr Wollman) Services, Wadsworth Veterans Administration Center, and the Departments of Surgery (Drs Williams and Wilson) and Pathology (Dr Wollman), UCLA Medical School, Los Angeles.
Footnotes
Accepted for publication Dec 30, 1980.
Read at the Fourth Annual Surgical Symposium of the Association of Veterans Administration Surgeons, Alexandria, Va, May 13, 1980.
Reprint requests to Surgical Service, Wadsworth VA Medical Center, Los Angeles, CA 90073 (Dr Wilson).
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