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Its Effect on Transit Time, Survival, and Weight Change After Massive Intestinal Resection

Joshua Careskey, MD; Thomas R. Weber, MD; Jay L. Grosfeld, MD

Arch Surg. 1981;116(5):618-622.

Abstract
• Sixty-five Sprague-Dawley rats underwent one of three procedures: (1) laparotomy without resection (n = 15); (2) 75% distal small-bowel resection, including the ileocecal valve (n = 25); and (3) 75% bowel resection, including ileocecal valve, and construction of a jejunal valve (n = 25). Rats were evaluated for survival, weight change, and transit time. Mortality was 0% in controls, 84% in group 2, and 28% in group 3 after three months. Rats with resection alone lost 29% of their initial weight, whereas rats with jejunal valves gained 24% over their preoperative weight. Transit time was three times slower in animals with valves. These data suggest that survival, transit time, and weight change are significantly improved in rats with massive bowel resection after construction of an artificial valve when compared with animals with resections alone. These observations imply that, in selected cases, an ileocecal valve replacement may have clinical usefulness.

(Arch Surg 1981;116:618-622)

Author Affiliations
From the Section of Pediatric Surgery, Department of Surgery, Indiana University School of Medicine and the James Whitcomb Riley Hospital for Children, Indianapolis.

Footnotes
Accepted for publication Dec 19, 1980.

Read before the 88th annual meeting of the Western Surgical Association, Salt Lake City, Nov 18, 1980.

Reprint requests to the James Whitcomb Riley Hospital for Children, 1100 W Michigan St, Indianapolis, IN 46223 (Dr Grosfeld).

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ABSTRACT