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Jaber S. Abbas, MD; Edward D. Holyoke, MD; Robert Moore, MS; Constantine P. Karakousis, MD

Arch Surg. 1981;116(6):765-769.

Abstract
• Cases of 251 patients with soft-tissue sarcoma of the extremities, trunk, head and neck, and retroperitoneum were reviewed. The overall five-, ten-, and 15-year survival rates were 45%, 30%, and 24%, respectively. The five-year survival rates after wide soft-tissue resections, local excision, and amputation were 59%, 42%, and 39%, respectively. Factors that significantly affected prognosis were tumor size, histologic type, local extent of the tumor, and the adequacy of the surgical procedure. The local recurrence rate was 36% after wide resection, 8% after amputation, and 65% after local excision. Local recurrence alone was treatable and evidenced overall five- and ten-year survival rates of 43% and 33%, respectively. Amputation was the most effective method to treat local recurrences in the extremities. Some guidelines are suggested to select high-risk patients for adjuvant treatment.

(Arch Surg 1981;116:765-769)

Author Affiliations
From the Departments of Surgical Oncology (Drs Abbas, Holyoke, and Karakousis) and Biostatistics (Mr Moore), New York State Department of Health, Roswell Park Memorial Institute, Buffalo.

Footnotes
Accepted for publication Feb 18, 1981.

Reprint requests to Roswell Park Memorial Institute, 666 Elm St, Buffalo, NY 14263 (Dr Karakousis).

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