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Their Significance After Major Hepatic Resection

Minoru Ukikusa, MD; Kazue Ozawa, MD; Yasuyuki Shimahara, MD; Motokazu Asano, MD; Toshio Nakatani, MD; Takayoshi Tobe, MD

Arch Surg. 1981;116(6):781-785.

Abstract
• Changes in the ratio of acetoacetate to 3-hydroxybutyrate (the ketone body ratio) in arterial blood were investigated after massive liver resection in patients and rabbits. In a patient who had had a successful hepatectomy, the blood ketone body ratio decreased rapidly after the operation and then returned to the preoperative level; whereas in a patient who had had an unsuccessful hepatectomy, the blood ketone body ratio did not decrease rapidly after the operation. In 70% hepatectomized rabbits, the blood ketone body ratio decreased maximally nine hours after hepatectomy and then returned gradually to a normal level. The blood ketone body ratio paralleled the hepatic energy charge after 70% hepatectomy in rabbits. The measurement of the blood ketone body ratio is very useful for evaluation of the energy status of the remnant liver.

(Arch Surg 1981;116:781-785)

Author Affiliations
From the Department of Surgery, Kyoto University Faculty of Medicine, Kyoto, Japan.

Footnotes
Accepted for publication Oct 21, 1980.

Reprint requests to Department of Surgery, Kyoto University Faculty of Medicine, 54-Kawara-cho, Shogoin, Sakyo-ku, Kyoto 606, Japan (Dr Ukikusa).

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