 |
|
Does Peutz-Jeghers Syndrome Predispose to Gastrointestinal Malignancy?A Later Look
Dimitrios A. Linos, MD;
Roger R. Dozois, MD;
David C. Dahlin, MD;
Lloyd G. Bartholomew, MD
Arch Surg. 1981;116(9):1182-1184.
Abstract
• Several reports have recently suggested an association between the development of intestinal carcinoma and the presence of Peutz-Jeghers syndrome. During the 45-year period between 1935 and 1979, 48 patients with Peutz-Jeghers syndrome were seen at the Mayo Clinic, Rochester, Minn, and followed up for a median period of 33 years. Carcinoma of the small or large intestine did not develop in any patient, with possibly one exception. Survival of patients with Peutz-Jeghers syndrome also was found to be similar to that of the general population. Therefore, skepticism continues about the premalignant potential of this rare syndrome, especially in the small intestine, and surgical conservatism should be practiced in its management.
(Arch Surg 1981;116:1182-1184)
Author Affiliations
From the Departments of Surgery (Drs Linos and Dozois) and Surgical Pathology (Dr Dahlin) and the Division of Gastroenterology and Internal Medicine (Dr Bartholomew), Mayo Clinic and Mayo Foundation, Rochester, Minn.
Footnotes
Accepted for publication April 20, 1981.
Reprint requests to Department of Surgery, Mayo Clinic, Rochester, MN 55905 (Dr Dozois).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
LKB1 and AMPK Family Signaling: The Intimate Link Between Cell Polarity and Energy Metabolism
Jansen et al.
Physiol. Rev. 2009;89:777-798.
ABSTRACT
| FULL TEXT
Clinical Diagnosis and Management of Hereditary Colorectal Cancer Syndromes
Vasen
JCO 2000;18:81s-92.
FULL TEXT
Localization of Peutz-Jeghers Macules to Psoriatic Plaques
Banse-Kupin and Douglass
Arch Dermatol 1986;122:679-683.
ABSTRACT
|
