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Clinical Correlations With Drug Sensitivities in the Clonogenic AssayA Retrospective Study
Barry D. Mann, MD;
David H. Kern, PhD;
Armando E. Giuliano, MD;
Martyn W. Burk, MD, PhD;
Mary Ann Campbell;
Larry R. Kaiser, MD;
Donald L. Morton, MD
Arch Surg. 1982;117(1):33-36.
Abstract
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• We tested the ability of the in vitro clonogenic assay (CLAS) to predict clinical response for patients with solid tumors. Patients had objectively measurable disease and received at least one course of chemotherapy. The correlation between clinical responses and in vitro sensitivity was evaluated retrospectively. Tumor types included melanoma (19), sarcoma (five), hepatoma (one), and carcinoma of the stomach (two), colon (three), lung (one), and breast (one). Five patients received two separate courses of chemotherapy with different drugs or drug regimens. In nine of 11 (82%) instances, tumors were sensitive to a particular drug, and the patient had at least 50% regression of tumor following treatment with the tested drug. Two patients whose tumors were sensitive in vitro had no evidence of clinical response. In 25 of 26 assays, the CLAS accurately predicted tumor resistance, and only one patient had evidence of clinical response (96%). Associations of in vitro results with clinical responses were highly significant. The CLAS can accurately predict the chemosensitivity of a variety of solid tumors.
(Arch Surg 1982;117:33-36)
Author Affiliations
From the Division of Oncology, Department of Surgery, UCLA School of Medicine (Drs Mann, Kern, Giuliano, Burk, Kaiser, and Morton); and the Surgical Service, Sepulveda Veterans Administration Hospital, Sepulveda, Calif (Drs Kern, Giuliano, Burk, and Morton and Ms Campbell).
Footnotes
Accepted for publication July 9, 1981.
Read at the annual meeting of the Southern California Chapter of the American College of Surgeons, Santa Barbara, Calif, Jan 24, 1981.
Reprint requests to Division of Surgical Oncology, Factor Building, UCLA School of Medicine, Los Angeles, CA 90024 (Dr Mann).
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