Indications for therapy for fungemia in postoperative patients
J. S. Solomkin, A. M. Flohr and R. L. Simmons
We reviewed the clinical courses of 63 surgical patients who had
experienced one or more days of fungemia, to determine the clinical setting
for such infections and to define indications for systemic therapy.
Fifty-one patients experienced fungemia as a late complication of
intraperitoneal infection. Candida was identified as part of a
polymicrobial flora in 70%. If untreated, the mortality was 83% (30 of 36).
No untreated patients with fungemia for more than one day survived.
Adequate therapy with amphotericin B (total dose, greater than 3 mg/kg)
improved survival to 67% (ten of 15). Autopsies performed in 20 cases
revealed visceral Candida microabscesses in seven, with the
gastrointestinal tract (12) and intraabdominal abscess (five) as the most
common sources of fungi. These data support the concept of Candida as an
important participant in polymicrobial infection and recommend therapy with
amphotericin B for patients with intraperitoneal infection experiencing
fungemia.
