 |
|
Platelet—Arterial Synthetic Graft Interaction and Its Modification
Allan D. Callow, MD;
Raymond Connolly, PhD;
Thomas F. O'Donnell, Jr, MD;
Ronald Gembarowicz, MD;
Ellen Keough, PhD;
Karen Ramberg-Laskaris, MS;
C. Robert Valeri, MD
Arch Surg. 1982;117(11):1447-1455.
Abstract
| |
• We compared the in vivo platelet reactivity of two commonly used clinical grafts, Dacron and expanded polytetrafluoroethylene (PTFE), with that of a control autogenous artery graft and assessed whether platelet reactivity was modified by the platelet-antiaggregating agent prostacyclin (PGI2) (epoprostenol). Grafts were randomly placed into the carotid arteries of 21 baboons. Platelets labeled with indium 111 were infused within one hour after implantation graft for gamma camera scanning of platelet uptake. The accumulation of platelets on Dacron grafts began almost immediately after injection and reached a peak after one to two hours. The PTFE and control autogenous artery grafts accumulated comparable small amounts of platelets. Prostacyclin was then infused in a second series of baboons with Dacron grafts, at a rate of 150 to 200 ng/kg/min. It prevented the usual platelet uptake when administered concomitant with graft implantation and reduced previously established platelet activity.
(Arch Surg 1982;117:1447-1455)
Author Affiliations
From the Departments of Surgery (Drs Callow, Connolly, O'Donnell, Gembarowicz, and Keough) and Nuclear Medicine (Ms Ramberg-Laskaris), Tufts-New England Medical Center, and the US Naval Blood Research Laboratory (Dr Valeri), Boston.
Footnotes
Accepted for publication Aug 5, 1982.
Read before the 30th scientific meeting of the International Cardiovascular Society, Boston, June 18, 1982.
Reprint requests to 171 Harrison Ave, Boston, MA 02111 (Dr Callow).
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Early Restenosis After Carotid Endarterectomy with Vein Patch Angioplasty
Tripathi and Deshmukh
VASC ENDOVASCULAR SURG 1997;31:761-767.
ABSTRACT
The Possibility of Distal Embolization From a Femoral-Popliteal Prosthesis Above the Knee: A Consideration Against Its Routine Use in This Position
Friedman and Krishnasastry
Arch Surg 1990;125:668-670.
ABSTRACT
Plasma Polymerized Tetrafluoroethylene/Polyethylene Terephthalate Vascular Prostheses
Greisler et al.
Arch Surg 1989;124:967-972.
ABSTRACT
Effect of a Selective Thromboxane Synthase Inhibitor on Arterial Graft Patency and Platelet Deposition in Dogs
McDaniel et al.
Arch Surg 1987;122:887-892.
ABSTRACT
Effect of Prolonged Intra-arterial Prostaglandin E1 Infusion on Canine Arterial Graft Patency
Cronenwett et al.
Arch Surg 1986;121:760-764.
ABSTRACT
Synthetic Arterial Graft Conduits
Jackson
VASC ENDOVASCULAR SURG 1984;18:354-358.
ABSTRACT
|
