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Effect of Increased Arterial Blood Flow on Localization and Progression of Atherosclerosis
Jonathan B. Towne, MD;
Kevin Quinn, MD;
Sergio Salles-Cunha, PhD;
Victor M. Bernhard, MD;
Lawrence J. Clowry, MD
Arch Surg. 1982;117(11):1469-1474.
Abstract
• Unilateral femoral arteriovenous fistulas were constructed in New Zealand white female rabbits that were subsequently placed on a 1% cholesterol diet for two months. Experimental animals were divided into three groups: group 1 (N =7), the fistula remained patent for two months; group 2 (N = 7), the fistula occluded after the first month of the observation period; and group 3 (N = 6), the fistula closed after the first month, but the rabbits were maintained on the cholesterol diet for a total of three months. In group 1, 59% (±13%) of the surface area of the donor iliac artery had atherosclerotic lesions compared with 18% (±3%) of the contralateral iliac artery. A similar distribution of atherosclerotic lesions was noted in groups 2 and 3. Increasing arterial blood flow did not have a protective effect on the donor artery but seemed to promote atherosclerosis.
(Arch Surg 1982;117:1469-1474)
Author Affiliations
From the Department of Surgery, Medical College of Wisconsin, Milwaukee.
Footnotes
Accepted for publication July 26, 1982.
Read before the 30th scientific meeting of the International Cardiovascular Society, Boston, June 18, 1982.
Reprint requests to Department of Surgery, Medical College of Wisconsin, 8700 W Wisconsin Ave, Milwaukee, WI 53226 (Dr Towne).
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