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  Vol. 117 No. 2, February 1982 TABLE OF CONTENTS
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Alterations in lipogenic enzymes and lipoprotein lipase activity during gram-negative sepsis in the rat

S. Lanza-Jacoby, S. C. Lansey, M. P. Cleary and F. E. Rosato

The effects of sepsis on lipid metabolism have not been clearly defined. This study was designed to observe the changes in adipose tissue lipoprotein lipase (LPL) and fatty acid synthetase (FAS) after administration of Escherichia coli bacteria. Male Lewis rats, weighing 245 to 270 g, were assigned to two groups and fed a powdered chow diet for 14 days. On day 14, one group was inoculated with E coli. Twenty-four hours later, both groups were killed by decapitation. Serum triglyceride levels were significantly elevated in the E coli-treated rats. Adipose tissue LPL and FAS activity was significantly decreased by 50% in E coli-treated rats compared with the control rats. These results suggest that the elevated serum triglyceride levels associated with sepsis maybe caused by a decreased rate of clearance of lipids from the blood and an increased rate of hepatic lipid synthesis.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Adipocyte, Adipose Tissue, and Infectious Disease
Desruisseaux et al.
Infect. Immun. 2007;75:1066-1078.
FULL TEXT  

In vitro effect of endotoxin on lipolysis and lipoprotein lipase activity in adipocytes from lean, obese and obese diabetic Zucker rats
Lanza-Jacoby et al.
Innate Immunity 1995;2:449-454.
ABSTRACT  





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