Alterations in Lipogenic Enzymes and Lipoprotein Lipase Activity During Gram-Negative Sepsis in the Rat

doi:10.1001/archsurg.1982.01380260028005

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Vol. 117 No. 2, February 1982

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Alterations in Lipogenic Enzymes and Lipoprotein Lipase Activity During Gram-Negative Sepsis in the Rat

Susan Lanza-Jacoby, PhD; Stephan C. Lansey; Margot P. Cleary, PhD; Francis E. Rosato, MD

Arch Surg. 1982;117(2):144-147.

Abstract

• The effects of sepsis on lipid metabolism have not beenclearly defined. This study was designed to observe the changesin adipose tissue lipoprotein lipase (LPL) and fatty acid synthetase(FAS) after administration of Escherichia coli bacteria. MaleLewis rats, weighing 245 to 270 g, were assigned to two groupsand fed a powdered chow diet for 14 days. On day 14, one groupwas inoculated with E coli. Twenty-four hours later, both groupswere killed by decapitation. Serum triglyceride levels weresignificantly elevated in the E coli–treated rats. Adiposetissue LPL and FAS activity was significantly decreased by 50%in E coli–treated rats compared with the control rats.These results suggest that the elevated serum triglyceride levelsassociated with sepsis may be caused by a decreased rate ofclearance of lipids from the blood and an increased rate ofhepatic lipid synthesis.

(Arch Surg 1982;117:144-147)

Author Affiliations

From the Department of Surgery, Jefferson Medical College, Philadelphia (Drs Lanza-Jacoby and Rosato and Mr Lansey) and the Department of Nutrition and Food Sciences, Drexel University, Philadelphia (Dr Cleary).

Footnotes

Accepted for publication July 23, 1981.

Read in part at the first annual meeting of the Surgical InfectionSociety, Chicago, April 25, 1981.

Reprint requests to Department of Surgery, Jefferson MedicalCollege, 1025 Walnut St, Philadelphia, PA 19107 (Dr Lanza-Jacoby).

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