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Single-Dose Intraoperative Antibiotic Prophylaxis in Emergency Abdominal Surgery
Brian J. Rowlands, MD, FRCS;
Ronald G. Clark, FRCS;
David G. Richards, FRCS
Arch Surg. 1982;117(2):195-199.
Abstract
In a randomized controlled trial of the use of a single intravenous dose of gentamicin sulfate and clindamycin phosphate used intraoperatively during emergency abdominal surgery, the overall incidence of postoperative wound infection was reduced from 32.3% to 10.4%. Significant reduction in wound infection occurred in the study group compared with control subjects, irrespective of the underlying pathologic lesion. No side effects of the use of antibiotics were noted. The policy of antibiotic prophylaxis in emergency surgery seems to be of particular benefit in elderly patients.
(Arch Surg 1982;117:195-199)
Author Affiliations
From the University Surgical Unit, Northern General Hospital, Sheffield, England. Dr Rowlands is now with the University of Texas Health Science Center, Houston.
Footnotes
Accepted for publication Sept 22, 1981.
Read at the first annual meeting of the Surgical Infection Society, Chicago, April 25, 1981.
Reprint requests to Department of Surgery, University of Texas Health Science Center, 6431 Fannin, Houston, TX 77030 (Dr Rowlands).
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