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A Prospective Randomized Study

Michael Mulholland, MD; Charles Morrow, MD; Daniel H. Dunn, MD; Michael L. Schwartz, MD, PhD; Edward W. Humphrey, MD, PhD

Arch Surg. 1982;117(4):393-397.

Abstract
From 1960 to 1980, 344 patients were included in a prospective randomized study for elective surgical treatment of duodenal ulcer disease. Results of vagotomy and pyloroplasty were compared with vagotomy and hemigastrectomy. There were no postoperative deaths, and the postoperative complication rates were similar for both groups. Ulcerations recurred in 12% of the vagotomy-pyloroplasty group and in 3% of the vagotomy-hemigastrectomy group (P <.05). Independent analyses of recurrence were performed for young patients, for alcoholics, and for patients who had obstructions or were bleeding preoperatively. Recurrence rates in these special populations were not found to be significantly different. Eight percent of the vagotomy-pyloroplasty group required reoperations for recurrent ulceration; only 2% of the vagotomy-hemigas-trectomy group required reoperations. Postoperative dumping symptoms were significantly more frequent in the vagotomyhemigastrectomy group. Postoperative diarrhea was also more frequent and more severe in the vagotomy-hemigastrectomy group.

(Arch Surg 1982;117:393-397)

Author Affiliations
From the Department of Surgery, University of Minnesota, Minneapolis (Drs Mulholland and Morrow) and the Department of Surgery, Minneapolis Veterans Administration Medical Center (Drs Dunn, Schwartz, and Humphrey).

Footnotes
Accepted for publication Nov 24, 1981.

Read at the Fifth Annual Surgical Symposium of the Association of Veterans Administration Surgeons, Minneapolis, May 15, 1981.

Reprint requests to Department of Surgery, Minneapolis Veterans Administration Medical Center, Minneapolis, MN 55417 (Dr Humphrey).

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