Deferred parathyroid autografts with cryopreserved tissue after reoperative parathyroid surgery
A. W. Saxe, A. M. Spiegel, S. J. Marx and M. F. Brennan
Between August 1975 and March 1981, 12 patients underwent forearm
parathyroid autotransplantation with cryopreserved tissue following
reoperative parathyroid surgery. Tissue had been cryopreserved two to 18
months. Follow-up ranged from four to 66 months (median, 18 months)
following autotransplantation. All patients required calcium
supplementation as a condition for autografting; six patients were no
longer receiving calcium supplementation at most recent follow-up and in
one patient the dosage was being tapered. The presence of a parathyroid
hormone gradient of 2 : 1 or greater correlated well with freedom from
calcium supplementation. Of seven patients with preautograft and
postautograft urinary cyclic adenosine monophosphate (cAMP) determinations,
three with increases following transplantation did not require calcium,
three without increases continued to require calcium, and the patient whose
dosage was being tapered had increased urinary cAMP levels.