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Mayo Clinic Experience

J. Kirk Martin, Jr, MD; S. Corbin Clark, MD; Robert W. Beart, Jr, MD; William H. ReMine, MD; William L. White, MD; Duane M. Ilstrup, MS

Arch Surg. 1982;117(5):586-591.

Abstract
• Between 1967 and 1979, 316 patients with Hodgkin's disease underwent staging laparotomy. Histologic examination demonstrated lymphocyte predominance in 40(12.7%) patients, nodular sclerosis in 178(56.3%), mixed cellularity in 80(25.3%), and lymphocyte depletion in seven (2.2%); results in 11 (3.5%) patients were considered unclassifiable. There were no deaths. Major complications occurred in 7.9% and required reoperation in 1.9%. Pathologic stage differed from clinical stage in 111 (35.1%) patients. In 90 (28.5%) patients, the stage advanced; in 21 (6.6%) patients, the stage was reduced; and in five (1.6%) patients, the histologic subtype was changed. Stage changes occurred in 40% of those with lymphocyte predominance, in 27.5% with nodular sclerosis, in 46.3% with mixed cellularity, and in 85.7% with lymphocyte depletion. The reliability of staging laparotomy for the determination of appropriate treatment favors its continued use.

(Arch Surg 1982;117:586-591)

Author Affiliations
From the Section of Gastroenterologic and General Surgery (Drs Martin, Clark, Beart, and ReMine), Division of Hematology and Internal Medicine (Dr White), and Section of Medical Research Statistics (Mr Ilstrup), Mayo Clinic and Mayo Foundation, Rochester, Minn.

Footnotes
Accepted for publication Dec 29, 1981.

Read before the 89th annual meeting of the Western Surgical Association, Albuquerque, Nov 17, 1981.

Reprint requests to Mayo Clinic, 200 First St SW, Rochester, MN 55905 (Dr Martin).

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