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Carl J. Hauser, MD; Cary Kaufman, MD; Robert Frantz, MD; Clay Shippy, MS; Sandra Schwartz, MS; William C. Shoemaker, MD

Arch Surg. 1982;117(6):782-786.

Abstract
• Replacement of a circulatory RBC mass was performed isovolemically in experimental dogs using either 7% crystalline hemoglobin solution with a low P₅₀ (the oxygen tension necessary to produce 50% saturation of hemoglobin at pH 7.4 and 37 °C) or with an albumin solution. Progressive RBC depletion caused increased cardiac output in both groups. Oxygen delivery was better preserved after using the crystalline hemoglobin solution, and, under conditions of extreme anemia, oxygen transport using this solution enabled dogs to survive the otherwise lethal insult. Although administration of crystalline hemoglobin preserved oxygen transport, oxygen off-loading was at a lower tension because of the lower P₅₀. Decreased mixed venous oxygen tension, which presumably reflects lower tissue oxygen tension, was associated with systemic vasoconstriction. The administration of oxygen-carrying solutions with low P₅₀ values results in a relatively vasoconstricted state. This vascular response is mediated by changes in tissue oxygen tension, rather than by impaired tissue oxygen consumption.

(Arch Surg 1982;117:782-786)

Author Affiliations
From the Department of Surgery, Los Angeles County Harbor-UCLA Medical Center, Torrance, Calif, and the UCLA School of Medicine, Los Angeles.

Footnotes
Accepted for publication July 13, 1981.

Reprint requests to Los Angeles County Harbor-UCLA Medical Center, 1000 W Carson St, Torrance, CA 90509 (Dr Shoemaker).

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