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Changes in Appearance When Associated With Colonic Neoplasia

Leon Morgenstern, MD; Larry Shemen, MD; Warren Allen, MD; Pamela Amodeo, MA; Stephen L. Michel, MD

Arch Surg. 1983;118(1):62-64.

Abstract
• In 30 cases of colonic neoplasia associated with melanosis coli, proliferating or neoplastic colonic epithelium was notable within the melanotic colons by virtue of a striking absence of pigmentation. Microscopically this characteristic was found to be due to an absence or diminution of pigment-laden macrophages in the lamina propria underlying such lesions. Therefore, the absence of pigment-laden macrophages can be considered a marker for abnormally proliferating epithelium. This characteristic may denote a cellular or humoral change mediated by macrophages in association with neoplastic epithelium.

(Arch Surg 1983;118:62-64)

Author Affiliations
From the Departments of Surgery (Drs Morgenstern, Shemen, and Michel and Ms Amodeo) and Pathology (Dr Allen), Cedars-Sinai Medical Center, Los Angeles.

Footnotes
Accepted for publication Aug 9, 1982.

Read before the annual meeting of the Southern California Chapter of the American College of Surgeons, Newport Beach, Calif, Jan 24, 1982.

Reprint requests to Department of Surgery, Cedars-Sinai Medical Center, PO Box 48750. Los Angeles, CA 90048 (Dr Morgenstern).

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