This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (6)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Experimental and Clinical Studies

Horng-Shi Chen, MD; Chun-Sheng Chung, MD; Tain-Cheng Wu, MD

Arch Surg. 1983;118(1):88-92.

Abstract
• To eliminate successfully the undesirable side effects of the highly selective vagotomy, we developed a new, simpler type of vagotomy. As it was thoroughly demonstrated in dogs, myotomy of the lesser gastric curvature and fundus of the stomach denervates the parietal cell mass. Preoperative and postoperative acid studies were carried out with histamine phosphate (0.4 mg/kg given intramuscularly) and insulin injection (0.2 units/kg given intravenously). After myotomy, the curve was shifted to the right in response to histamine; insulin response was completely abolished. These results provided the basis for treatment of duodenal ulcer in a human patient and confirmed that the operation is capable of producing satisfactory secretory inhibition. Our early experimental and clinical results have been encouraging. Therefore, we support further investigation regarding clinical application of this method in the treatment of chronic duodenal ulcers.

(Arch Surg 1983;118:88-92)

Author Affiliations
From the Department of Surgery, National Defense Medical Center and Tri-Service General Hospital, Taipei, Taiwan. Dr Wu is now with the Veterans General Hospital, Taipei.

Footnotes
Accepted for publication June 23, 1982.

Read before the 28th Semiannual Conference of the Surgical Association of the Republic of China, Tainan, Taiwan, Sept 27, 1981.

Reprints not available.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?