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Experimental Validation of the Role of Central and Regional Hemodynamics

Richard P. Cambria, MD; Raphael Walden, MD; Joseph Megerman, PhD; Gilbert L'Italien; William M. Abbott, MD

Arch Surg. 1983;118(10):1152-1156.

Abstract
• We developed an experimental model of graded arterial stenosis to emulate conditions that might be encountered immediately following arterial grafting. Noninvasive measurements of systolic BP and limb blood flow were recorded with a Doppler probe and segmental air plethysmography, respectively, under conditions of different cardiac output and local arterial resistance. These measurements were correlated with direct intra-arterial pressure recordings and flow measurements taken with an electromagnetic flowmeter. There was an excellent correlation between noninvasive and intra-arterial measurements of systolic pressure over a range of cardiac outputs and degree of arterial stenosis. Pulse volume recordings correlated with direct measurements of blood flow at high and baseline cardiac outputs, but the calibration of pulse volume amplitude varied between cuff applications in this canine model. Noninvasive intraoperative monitoring techniques can faithfully represent known physiologic responses to graded arterial stenoses, irrespective of a high cardiac output or peripheral vasodilation.

(Arch Surg 1983;118:1152-1156)

Author Affiliations
From the Department of Surgery, Massachusetts General Hospital (Drs Cambria, Walden, Megerman, and Abbott and Mr L'Italien) and the Harvard Medical School (Drs Cambria, Walden, Megerman, and Abbott) Boston.

Footnotes
Accepted for publication March 21, 1983.

Reprint requests to Department of Surgery, Massachusetts General Hospital, Fruit Street, Boston, MA 02114 (Dr Abbott).

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