You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


Advertisement

ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | RSS | Access Rights | Sign In


  Vol. 118 No. 11, November 1983 TABLE OF CONTENTS
  Online Only
 •  Online First Table of
Contents
  ORIGINAL ARTICLES
 •Online Features
 This Article
 •References
 •Full text PDF
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Citing articles on Web of Science (207)
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Delicious Add to Digg Add to Facebook Add to Reddit Add to Technorati Add to Twitter What's this?

Metabolic Abnormalities Associated With Postoperative Organ Failure

A Redox Theory

Kazue Ozawa, MD; Hidehisa Aoyama, MD; Kazuhiro Yasuda, MD; Yasuyuki Shimahara, MD; Toshio Nakatani, MD; Junji Tanaka, MD; Masayuki Yamamoto, MD; Yasuo Kamiyama, MD; Takayoshi Tobe, MD

Arch Surg. 1983;118(11):1245-1251.


Abstract



• We studied metabolic abnormalities of postoperative organ failure in 55 patients and classified them into four groups according to the postoperative changes in the arterial blood—ketone body ratio (acetoacetic acid–β-hydroxybutyric acid) reflecting hepatic mitochondrial redox potential: patients in group A had no decrease below 0.7, patients in group B had a transient decrease to 0.4, patients in group C had a progressive decrease to below 0.4, and patients in group D (terminal stage) had a decrease to below 0.25. All group A and B patients tolerated their operations well; the group C and D patients had multiple organ failure. In groups B, C, and D, plasma concentrations of alanine, proline, phenylalanine, and tyrosine were negatively correlated with the blood—ketone body ratio and the molar ratios between the plasma concentrations of branchedchain amino acids and aromatic amino acids were positively correlated with the blood—ketone body ratio. Hepatic energy deficit associated with decreasing blood-ketone body ratio may be the metabolic basis of postoperative organ failure.

(Arch Surg 1983;118:1245-1251)



Author Affiliations



From the Department of Surgery, Kyoto (Japan) University Medical School.


Footnotes



Accepted for publication March 3, 1983.

Reprint requests to Department of Surgery, Kyoto University Medical School, 54-Kawaracho, Shogoin, Sakyo-ku, Kyoto 606, Japan (Dr Ozawa).



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Delicious Delicious   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Study in three different types of cardiopulmonary bypass on arterial ketone body ratio: its prognostic implication and participation of body temperature
Nakamura et al.
Interact CardioVasc Thorac Surg 2003;2:25-29.
ABSTRACT | FULL TEXT  

Hepatic dysfunction after left ventricular mechanical assist in patients with end-stage heart failure: role of inflammatory response and hepatic microcirculation
Masai et al.
Ann. Thorac. Surg. 2002;73:549-555.
ABSTRACT | FULL TEXT  

Superior hepatic mitochondrial oxidation-reduction state in normothermic cardiopulmonary bypass
Hashimoto et al.
J. Thorac. Cardiovasc. Surg. 2001;121:1179-1186.
ABSTRACT | FULL TEXT  

TNF-{alpha} and IL-6 Synergistically Inhibit Ketogenesis From Fatty Acids and {alpha}-Ketoisocaproate in Isolated Rat Hepatocytes
Pailla et al.
JPEN J Parenter Enteral Nutr 1998;22:286-290.
ABSTRACT  

Functional Contribution of Preoperative Portal Vein Occlusion to Hepatectomy: With Special Reference to Hepatic Energy Charge and DNA Synthesis After Hepatectomy in Rats
Chijiiwa et al.
Arch Surg 1996;131:779-784.
ABSTRACT  

Monitoring of hepatic venous oxygen saturation for predicting acute liver dysfunction after Fontan operations
Takano et al.
J. Thorac. Cardiovasc. Surg. 1994;108:700-708.
ABSTRACT | FULL TEXT  

Triiodothyronine Resuscitates the Impaired Liver Function After Pringle's Maneuver
Okamoto et al.
Arch Surg 1994;129:851-856.
ABSTRACT  

Efficiency of a Centrifugal Pump for Distal Circulatory Support During Cross-clamping of the Descending Thoracic Aorta
Gang Liu et al.
VASC ENDOVASCULAR SURG 1994;28:167-176.
ABSTRACT  

Noninvasive Evaluation of Cytochrome c Oxidase Activity of the Liver: Its Prognostic Value for Hepatic Resection
Ueda et al.
Arch Surg 1994;129:303-308.
ABSTRACT  

Impact of Exogenous Insulinlike Growth Factor 1 on Hepatic Energy Metabolism in Burn Injury
Dong et al.
Arch Surg 1993;128:703-708.
ABSTRACT  

Postoperative Intra-abdominal Sepsis Requiring Reoperation: Value of a Predictive Index
Pusajo et al.
Arch Surg 1993;128:218-223.
ABSTRACT  

Total Vascular Exclusion for Hepatic Resection in Cirrhotic Patients: Application of Venovenous Bypass
Yamaoka et al.
Arch Surg 1992;127:276-280.
ABSTRACT  

Cytochrome c Oxidase Activity in Human Liver Specimens: An Index of Prognosis for Hepatic Resection
Sakai et al.
Arch Surg 1990;125:632-635.
ABSTRACT  

Changes in Arterial Ketone Body Ratio in the Phase Immediately After Hepatectomy: Prognostic Implications
Kiuchi et al.
Arch Surg 1990;125:655-659.
ABSTRACT  

Septic Encephalopathy: Evidence for Altered Phenylalanine Metabolism and Comparison With Hepatic Encephalopathy
Mizock et al.
Arch Intern Med 1990;150:443-449.
ABSTRACT  

Controversies in Lactic Acidosis: Implications in Critically III Patients
Mizock
JAMA 1987;258:497-501.
ABSTRACT  

Kupffer Cell Modulation of the Systemic Immune Response
Marshall et al.
Arch Surg 1987;122:191-196.
ABSTRACT  

Multiple-Organ Failure: Generalized Autodestructive Inflammation?
Goris et al.
Arch Surg 1985;120:1109-1115.
ABSTRACT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | PHYSICIAN JOBS | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1983 American Medical Association. All Rights Reserved.