Recipient race as a risk factor in renal transplantation
P. J. Garvin, M. Castaneda, J. E. Codd and K. Mauller
We analyzed 118 renal transplants performed from November 1977 through
October 1981 to determine the effect of recipient race on graft and patient
survival. Fifty-one cadaver and three living related transplants were
performed in the black recipients and 41 cadaver and 23 living related
transplants in the white recipients. No significant differences existed
between the groups in regard to age, incidence of pretransplant nephrectomy
or splenectomy, warm ischemia time, perfusion time, panel-reactive
alloantibody (PRA) status, or number of pretransplant blood transfusions.
The mean HLA-A and -B locus match was significantly less in black cadaver
recipients and the incidence of malignant hypertension was significantly
greater in black recipients. The one-year graft survival rate was 54.9% for
black cadaver recipients and 48.7% for white cadaver recipients with a
corresponding patient survival rate of 86.2% and 85.3%. The one-year graft
survival rate for living-related recipients was 100% for blacks and 73.9%
for whites with a corresponding patient survival rate of 100% and 86.9%.
These results were not significantly different. When the recipients were
matched for age, pretransplant transfusions, HLA-A and -B locus matching,
and PRA status, no difference in transplant outcome was identified. We
concluded that recipient race is not of prognostic significance in
determining the outcome of either cadaver or living related donor
transplantation.
