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Gamma Scintigraphic Localization of Platelets Labeled With Indium 111 in a Focus of Infection
Harvey J. Sugerman, MD;
James L. Tatum, MD;
Jerry I. Hirsch, PharmD;
David E. Sharp, MD, PhD;
Ghulam D. Qureshi, MD;
Philip B. Hylemon, PhD
Arch Surg. 1983;118(2):185-189.
Abstract
• To determine if autologous platelets would localize in a focus of infection, a pyogenic abscess was created in the left hind limb of dogs, using previously processed human stool, while an identical surgical procedure without bacterial inoculation was performed on the right hind limb. Autologous platelets labeled with indium 111(500 µCi) were administered intravenously to five control dogs that had not undergone surgery, to eight dogs two hours following stool inoculation, and to five dogs 24 hours after stool inoculation. A statistically significant scintigraphic increase in tracer activity was apparent within 24 hours in each animal at the site of abscess creation. Tissue samples, obtained at 48 hours after the administration of labeled platelets, revealed a significant increase in percent dose of 111In per gram of infected muscle compared with control muscle. These studies show that platelets localize at the site of bacterial infection.
(Arch Surg 1983;118:185-189)
Author Affiliations
From the Departments of Surgery (Dr Sugerman), Radiology (Drs Tatum and Hirsch), Pathology (Dr Sharp), and Medicine (Drs Qureshi and Hylemon), Medical College of Virginia/Virginia Commonwealth University, Richmond.
Footnotes
Accepted for publication Sept 13, 1982.
Read before the second annual meeting of the Surgical Infection Society, Boston, April 19, 1982.
Reprint requests to Box 519, MCV Station, Richmond, VA 23298 (Dr Sugerman).
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ABSTRACT
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