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Third-Generation Cephalosporins for Polymicrobial Surgical Sepsis
H. Harlan Stone, MD;
Priscilla R. Strom, MD;
Timothy C. Fabian, MD;
William E. Dunlop, MD
Arch Surg. 1983;118(2):193-200.
Abstract
• During 31 months of study, 808 patients with polymicrobial surgical infection were randomized for antibiotic therapy between a third-generation cephalosporin (moxalactam disodium [149], cefotaxime sodium [125], and cefoperazone sodium [141]) and the combination of gentamicin sulfate plus clindamycin (393). Results based on antibiotic therapy included the following: cure in 83% given cephalosporin, 73% with antibiotic combination; control but recurrent sepsis in 7% and 15%; and failure in 4% and 8%, respectively. Such data support the tenet that third-generation cephalosporins are at least equal, if not superior, to the combination of gentamicin plus clindamycin for treatment of polymicrobial surgical sepsis.
(Arch Surg 1983;118:193-200)
Author Affiliations
From the Department of Surgery, Emory University School of Medicine, Atlanta.
Footnotes
Accepted for publication Sept 7, 1982.
Read before the second annual meeting of the Surgical Infection Society, Boston, April 19, 1982.
Reprint requests to Department of Surgery, Emory University School of Medicine, 69 Butler St, Atlanta, GA 30303 (Dr Stone).
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