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Subeschar Treatment of Burn-Wound Infection
William F. McManus, MD;
Cleon W. Goodwin, Jr, MD;
Basil A. Pruitt, Jr, MD
Arch Surg. 1983;118(3):291-294.
Abstract
Within a 24-month period, 454 patients were admitted with burns (average size, 33% of the total body surface [TBS]). Wound infection developed in 19, who subsequently were treated with subeschar antibiotics. The average burn size in those 19 patients was 63% of the TBS, with an average full-thickness injury of 47%. Five (26%) of the 19 survived, and five others died without evidence of wound infection, giving a wound clearance rate of 52.6%. The five surviving patients (average burn size, 59% TBS) underwent excision of infected tissue, with split-thickness cutaneous autograft closure of the burn wound, after the course of subeschar antibiotic infusion. All surviving patients were infected with Pseudomonas aeruginosa. Subeschar infusion of semisynthetic penicillins, therefore, is an effective adjunct in the care of the patient with Pseudomonas burn-wound infection.
(Arch Surg 1983;118:291-294)
Author Affiliations
From the US Army Institute of Surgical Research, Fort Sam Houston, San Antonio, Tex.
Footnotes
Accepted for publication Nov 23, 1982.
Read before the second annual meeting of the Surgical Infection Society, Boston, April 20, 1982.
The views of the authors do not purport to reflect the positions of the Department of the Army or the Department of Defense.
Reprint requests to US Army Institute of Surgical Research, Fort Sam Houston, San Antonio, TX 78234 (Dr McManus).
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