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Surgical Treatment of Functioning Metastatic Carcinoid Tumors
J. Kirk Martin, Jr, MD;
Charles G. Moertel, MD;
Martin A. Adson, MD;
Allan J. Schutt, MD
Arch Surg. 1983;118(5):537-542.
Abstract
• Thirteen patients with functioning carcinoid syndrome and hepatic metastases were surgically treated. Localized hepatic metastases were resected in five patients, and diffuse hepatic metastases were treated with hepatic artery ligation in eight. There were no postoperative deaths, and follow-up ranged from six to 46 months. All patients were symptom-free after operation. In all patients with resection, levels of 5-hydroxyindoleacetic acid (5-HIAA) returned to normal or near normal, whereas in patients who underwent hepatic artery ligation, the average reduction in 5-HIAA level was 76%. Three patients died during the follow-up period—two of metastatic carcinoids and one without evidence of disease. The mean duration of response was 36 months for resection and 4.8 months for hepatic artery ligation. The addition of postoperative intra-arterial chemotherapy and sequential systemic chemotherapy may enhance the response to hepatic artery ligation.
(Arch Surg 1983;118:537-542)
Author Affiliations
From the Department of Surgery (Drs Martin and Adson) and the Division of Medical Oncology (Drs Moertel and Schutt), Mayo Clinic and Mayo Foundation, Rochester, Minn.
Footnotes
Accepted for publication Jan 3, 1983.
Read before the 90th annual meeting of the Western Surgical Association, Kansas City, Mo, Nov 15, 1982.
Reprint requests to Mayo Clinic, 200 First St SW, Rochester MN 55905 (Dr Martin).
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ABSTRACT
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