Continued propranolol administration following coronary bypass surgery. Antiarrhythmic effects
R. M. Abel, H. M. van Gelder, I. H. Pores, J. Liguori, I. Gielchinsky and V. Parsonnet
One hundred consecutive patients requiring propranolol hydrochloride before
undergoing isolated aortocoronary bypass procedures were examined. In half
the patients, propranolol therapy was discontinued, whereas the other half
continued to receive intraoperative and postoperative propranolol
regardless of clinical events. Although there were no preoperative
differences in the apparent degree of coronary arterial disease or left
ventricular function in the two groups, postoperative supraventricular
arrhythmias were less frequent in the propranolol-treated group, most
noticeably in those receiving less than 320 mg preoperatively. In patients
who had received large preoperative doses (greater than or equal to 320
mg/day), there were no significant differences in postoperative
supraventricular tachycardias. Continued propranolol therapy following
isolated coronary bypass surgery appears to be a safe and efficacious
method of decreasing the incidence of postoperative supraventricular
tachycardias.
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