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Its Use in 72-Hour Preservation of Dog Kidneys

Robert M. Hoffmann; James H. Southard, PhD; Mary Lutz; Armand Mackety; Folkert O. Beizer, MD

Arch Surg. 1983;118(8):919-921.

Abstract
• Hydroxyethyl starch (HES) was used as the sole colloid for oncotic support in a perfusate for successful (12 of 12 survivors) 72-hour kidney preservation by hypothermic-pulsatile perfusion. Posttransplant renal function was consistently better than that obtained with other perfusates commonly used in continuous perfusion preservation. Often the posttransplant serum creatinine levels rose to only 1.6 mg/dL and rapidly returned to normal (1.0 mg/dL). The perfusate included, in addition to HES, gluconate as the major anion in place of chloride. Perfusate containing high levels of potassium produces results equal to those with high levels of sodium. This is, to our knowledge, the first report of consecutive successful 72-hour preservation of canine kidneys using a purely synthetic perfusate devoid of animal-derived protein for colloid oncotic support.

(Arch Surg 1983;118:919-921)

Author Affiliations
From the Department of Surgery, University of Wisconsin Clinical Science Center, Madison.

Footnotes
Accepted for publication Oct 26, 1982.

Reprint requests to Clinical Science Center, 600 Highland Ave, Madison, WI 53792 (Dr Southard).

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