This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Thomas W. Klamer, MD; William L. Donegan, MD; Martin H. Max, MD

Arch Surg. 1983;118(8):933-935.

Abstract
• The use of subcutaneous mastectomy in women at high risk for breast cancer is based on the assumption that surgical reduction of the tissue at risk results in a corresponding reduction in risk. To assess the validity of this assumption in an animal model, we subjected 120 female Sprague-Dawley rats to the mammary carcinogen 7,12-dimethylbenz()anthracene and a 20% fat diet. Two days later, one mammary ridge was excised in half of the animals (mastectomy group), and a midline incision was made without excision of tissue in the other half (control group). Seventy-nine rats survived dosing and operation and were observed for 77 weeks. After 15 weeks, 17 of 39 controls and seven of 40 animals with mastectomies had histologically confirmed neoplastic tumors of the breast. However, after 77 weeks, 32 of 39 controls and 35 of 40 animals in the mastectomy group had neoplastic tumors. The incidence of carcinogen-induced mammary neoplasms in rats progressed with time; whereas surgical reduction of breast tissue was followed by early reduction in neoplasias, the difference was not maintained.

(Arch Surg 1983;118:933-935)

Author Affiliations
From the Department of Surgery, Medical College of Wisconsin, Milwaukee (Drs Klamer and Donegan), and Eastern Virginia Medical School, Norfolk (Dr Max).

Footnotes
Accepted for publication March 1, 1983.

Read before the Association for Academic Surgery, Chicago, Nov 9, 1981.

Reprint requests to Department of Surgery, Medical College of Wisconsin, 8700 W Wisconsin Ave, Milwaukee, WI 53226 (Dr Klamer).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

ASCO/SSO Review of Current Role of Risk-Reducing Surgery in Common Hereditary Cancer Syndromes
Guillem et al.
JCO 2006;24:4642-4660.
ABSTRACT | FULL TEXT  

Prophylactic Surgery in Women With a Hereditary Predisposition to Breast and Ovarian Cancer
Eisen et al.
JCO 2000;18:1980-1995.
ABSTRACT | FULL TEXT  

One-Stage Simple Mastectomy With Immediate Reconstruction for High-Risk Patients: An Improved Technique: The Biologic Basis for Ductal-Glandular Mastectomy
Bland et al.
Arch Surg 1986;121:221-225.
ABSTRACT