This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

John L. Ninnemann, PhD; Robert J. Stratta, MD; Glenn D. Warden, MD; Jeffrey R. Saffle, MD; Mark E. Weber

Arch Surg. 1984;119(1):33-38.

Abstract
• Circulating mediators have been implicated in the pathophysiology of immunodepression after burn injury, suggesting the beneficial effect of plasma exchange in immunorestoration. In this study, 19 adult patients with a mean burn size of 52.2% of total body surface area and mean age of 33.4 years underwent 51 plasma exchange procedures in five different clinical settings, without complication. The suppressive effect of burn serum was assayed in mixed lymphocyte cultures. The mean (±SEM) suppression by burn serum drawn prior to plasma exchange was 61.9%±3.6%, while that following plasma exchange was 27.3%±2.7%. The lymphocyte response decreased 55.1%±4.4% in suppressive activity. The mean duration of improvement in lymphocyte function was 4.8 days. Plasma exchange has a significant beneficial effect in restoring lymphocyte immunocompetence in burned patients in a number of clinical settings.

(Arch Surg 1984;119:33-38)

Author Affiliations
From the Department of Surgery and the Intermountain Burn Center, University of Utah Medical Center, Salt Lake City.

Footnotes
Accepted for publication Sept 8, 1983.

Read before the Third Annual Meeting of the Surgical Infection Society, Fort Lauderdale, Fla, May 7, 1983.

Reprint requests to Surgical Immunology Laboratory, University of Utah Medical Center, 50 N Medical Dr, Salt Lake City, UT 84132 (Dr Ninnemann).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?