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Relationship to Adequate Bacterial Defenses

Vincent Buffone; Jonathan L. Meakins, MD, DSc; Nicolas V. Christou, MD, PhD

Arch Surg. 1984;119(1):39-43.

Abstract
• Chemotaxis under agarose and the β-glucosaminidase enzyme-release assay (BGERA) were evaluated for assessing neutrophil function in 44 patients in a surgical intensive care unit (SICU). The 27 patients shown to be angeric to delayed-type hypersensitivity skin tests at entry to the SICU had decreased neutrophil chemotaxis of 2.6 ± 0.2cm (mean ± SEM) and a decreased BGERA result of 22.4%±1.6%. Major sepsis developed in 59% of them, and 44% died. The ten relatively anergic patients (reacting to one antigen) had a normal neutrophil chemotactic response of 3.0±0.2cm and a decreased BGERA result of 20.9%±1.6%. Sepsis developed in 30% of them, and 20% died. The seven reactive patients (reacting to two or more antigens) had a neutrophil chemotaxis of 3.7±0.3 cm and a BGERA result of 18.9%±1.7%. None had sepsis or died. The agarose method correlated best with the delayed-type hypersensitivity response. The BGERA results did not correlate with neutrophil chemotaxis and were not helpful in gauging neutrophil function.

(Arch Surg 1984;119:39-43)

Author Affiliations
From the Departments of Surgery (Mr Buffone and Drs Meakins and Christou) and Microbiology (Drs Meakins and Christou), Royal Victoria Hospital, and McGill University, Montreal.

Footnotes
Accepted for publication Sept 7, 1983.

Read before the Third Annual Meeting of the Surgical Infection Society, Fort Lauderdale, Fla, May 9, 1983.

Reprint requests to Royal Victoria Hospital, Room S10.30, 687 Pine Ave W, Montreal, Quebec, Canada H3A 1A1 (Dr Christou).

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