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Treatment With Low-Dose Adenosine Triphosphate-Magnesium Chloride

Paul F. McDonagh, PhD; Hillel Laks, MD; Irshad H. Chaudry, PhD; Arthur E. Baue, MD

Arch Surg. 1984;119(12):1379-1384.

Abstract
• To evaluate the effects of adenosine 5¹-triphosphate-magnesium chloride ATP-MgCl₂) on myocardial function following ischemia, mongrel dogs were placed on cardiopulmonary bypass with separate coronary perfusion pressures at 80 mm Hg. An intraventricular balloon was used to assess cardiac function as the area under the pressure-volume curve (PV), compliance (C), and cardiac contractility (dP/dT). Control measurements were made of coronary flow (Q), myocardial oxygen consumption and PV, C, and dP/dT. Myocardial ischemia was then induced for 45 minutes, followed by reperfusion (R). In group 1 (n=5), no ATP-MgCl₂ was infused into the coronary perfusion line. In group 2 (n=5), low-dose ATP-MgCl₂ (0.13 mg/min/kg) was infused during the first 30 minutes of reperfusion (R₀ to R₃₀), and in group 3 (n=5), high-dose ATP-MgCl₂ (3.2 mg/min/kg) was infused from R₀ to R₃₀. Use of ATP-MgCl₂ therapy produced marked coronary vasodilation. After 20 minutes of reperfusion (R₂₀), coronary resistance was 81%±12%, 55%±15%, and 31%±3% of control in groups 1, 2, and 3, respectively. The high-dose ATP-MgCl₂ (group 3) caused a marked systemic hypotension, but the low-dose ATP-MgCl₂ (group 2) did not. After 75 minutes of reperfusion (R₇₅), compliance was decreased in all groups. In groups 1 and 3, both function (PV) and dP/dT were significantly decreased. However, for group 2 (low-dose ATP-MgCl₂), function (PV), and dP/dT were not different from the control group, indicating an excellent recovery. Thus, at low doses, ATP-MgCl₂ appears to be a promising adjunct to the treatment of the ischemic myocardium.

(Arch Surg 1984;119:1379-1384)

Author Affiliations
From the Department of Surgery, Yale University School of Medicine, New Haven, Conn. Dr McDonagh is now with Texas Tech University Health Sciences Center, Lubbock.

Footnotes
Accepted for publication June 12, 1984.

Presented in part at the fall meeting of the American Physiological Society, San Diego, Oct 12, 1982.

Reprint requests to Texas Tech University Health Sciences Center, School of Medicine, 3601 Fourth St, Lubbock, TX 79430 (Dr McDonagh).