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Effects of Vitamin A and Beta Carotene on Intra-abdominal Sepsis
Achilles A. Demetriou, MD, PhD;
Israel Franco, MD;
Staffan Bark, MD;
Giuseppe Rettura, PhD;
Eli Seifter, PhD;
Stanley M. Levenson, MD
Arch Surg. 1984;119(2):161-165.
Abstract
• Vitamin A may play a role systemically and locally in controlling intra-abdominal sepsis. Adult male rats were divided into three groups. Group 1 ate a standard rat laboratory chow (not vitamin A deficient), group 2 ate the same chow supplemented with vitamin A, and group 3 ate the chow supplemented with beta carotene. All animals underwent cecal ligation, and the cecum was perforated either with a 27-gauge or an 18-gauge needle. Vitamin A dietary supplementation had a significant protective effect, which was manifested by improved survival in the animals whose cecum was perforated with an 18-gauge needle, prevention of postoperative hypothermia, maintenance of peripheral WBC counts at normal or above-normal values, and better localization of the intra-abdominal inflammatory process. Dietary supplementation with beta carotene had a lesser protective effect.
(Arch Surg 1984;119:161-165)
Author Affiliations
From the Departments of Surgery (Drs Demetriou, Franco, Bark, Rettura, Seifter, and Levenson) and Biochemistry (Dr Seifter), Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY.
Footnotes
Accepted for publication Sept 16, 1983.
Read before the Third Annual Meeting of the Surgical Infection Society, Fort Lauderdale, Fla, May 9, 1983.
Reprint requests to Department of Surgery, Albert Einstein College of Medicine, Room 740, Forchheimer Bldg, 1300 Morris Park Ave, Bronx, NY 10461 (Dr Demetriou).
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