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The Effect of Inspired Oxygen on Infection

David R. Knighton, MD; Betty Halliday; Thomas K. Hunt, MD

Arch Surg. 1984;119(2):199-204.

Abstract
• Granulocytes' in vitro bactericidal capacity for certain bacteria depends on an adequate environmental oxygen supply. Oxygen available to granulocytes in infected tissue is decreased by local conditions and can be altered significantly by small changes in its inspired concentration. We modified Burke's and Miles' bacteria-injection model in animals to test the effect of breathing 12%, 21%, and 45% oxygen on the size of lesions produced by intradermal injections of Escherichia coli. Moderately increased inspired oxygen concentrations (fraction of inspired oxygen [Fio₂]) significantly decreased the size and number of necrotic lesions, whereas hypoxia increased both. Increasing Fio₂ to 45% after three and 24 hours of hypoxia also significantly decreased lesion size. Suppression of infection by moderate hyperoxia is comparable with that reported by Burke after timely, adequate doses of type-specific antibiotics.

(Arch Surg 1984;119:199-204)

Author Affiliations
From the Department of Surgery, University of California, San Francisco.

Footnotes
Accepted for publication Aug 25, 1983.

Read before the Third Annual Meeting of the Surgical Infection Society, Fort Lauderdale, Fla, May 10, 1983.

Reprint requests to Department of Surgery, University of California, San Francisco, San Francisco, CA 94143 (Dr Knighton).

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