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Jerome J. Schentag, PharmD; David O'Keeffe; Mary Marmion; Philip B. Wels, MD

Arch Surg. 1984;119(3):300-304.

Abstract
• C-reactive protein (CRP) concentrations were monitored serially in 97 patients with abdominal sepsis to determine if differences in infection type or site would produce diagnostic or prognostic CRP level elevations. After surgery and abdominal infection, the average (± SD) CRP peak values were 21.2 ± 9.0 mg/dL. The CRP values rose markedly with infection, rose further with surgery, and subsided to less than 10 mg/dL with cure. Persistent levels of more than 10 mg/dL indicated abscess formation or continued infection. The average normal value at complete tissue healing after resolution of infection was 1.2 mg/dL, which was not different from that for healthy volunteers. Analysis suggested that CRP concentrations were not predictive of the type, site, or severity of abdominal infection; however, since persistent elevations were frequently associated with new or unresolved bacterial infection, serial determinations may be helpful in monitoring the course of disease and response to treatment.

(Arch Surg 1984;119:300-304)

Author Affiliations
From the Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo (Dr Schentag) and the Clinical Pharmacokinetics Laboratory (Dr Schentag, Mr O'Keeffe, and Ms Marmion), and Department of Surgery (Dr Wels), Millard Fillmore Hospital, Buffalo.

Footnotes
Accepted for publication Aug 15, 1983.

Reprint requests to Clinical Pharmacokinetics Laboratory, Millard Fillmore Hospital, 3 Gates Circle, Buffalo, NY 14209 (Dr Schentag).

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