This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (5)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Joseph A. Caruana, MD; Carl Sunby, MD; Daniel S. Camara, MD; Hao-Hui Chen, MD; Gerald Schneeberger

Arch Surg. 1984;119(4):437-441.

Abstract
• We compared alterations In circulating levels of insulin and glucagon and metabolic fuels in response to partial (70%) hepatectomy (HP) and sham hepatectomy (SHP) in fasting rats and in unanesthetized, fasting control rats. Within 15 minutes, animals in the HP group were hypoglycemic compared with the SHP and control groups. After 30 minutes, the insulin concentration and the insulin-glucagon molar ratio (IGR) rose in the HP group. After four hours, animals in the HP group were hyperglycemic compared with the SHP and control animals. Comparison of the lipid and amino acid profiles suggested use of these substrates by eight hours. The levels of branched-chain amino acids, although depressed early after HP, were markedly elevated later, when the IGR in the HP group had normalized. The acute loss of hepatic mass by limiting gluconeogenesis may be the cause of hypoglycemia and also could alter the plasma IGR because of the different hepatic clearance rates of these hormones. A switch to lipid and protein as metabolic fuels appears to follow these early changes.

(Arch Surg 1984;119:437-441)

Author Affiliations
From the Departments of Surgery (Drs Caruana, Sunby, and Chen, and Mr Schneeberger) and Medicine (Dr Camara), Veterans Administration Medical Center, Buffalo, and the State University of New York at Buffalo.

Footnotes
Accepted for publication Dec 21, 1983.

Read before the Seventh Annual Surgical Symposium of the Association of Veterans Administration Surgeons, Airlie, Va, May 27, 1983.

Reprint requests to Department of Surgery, VA Medical Center, 3495 Bailey Ave, Buffalo, NY 14215 (Dr Caruana).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Preoperative Fasting Improves Survival After 90% Hepatectomy
Sarac et al.
Arch Surg 1994;129:729-733.
ABSTRACT