This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (30)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Silent Lesions of the Pancreas?

William E. Strodel, MD; Aaron I. Vinik, MD; Ricardo V. Lloyd, MD; Benjamin Glaser, MD; Frederic E. Eckhauser, MD; Richard G. Fiddian-Green, MD; Jeremiah G. Turcotte, MD; Norman W. Thompson, MD

Arch Surg. 1984;119(5):508-514.

Abstract
• Eight patients with pancreatic polypeptide (PP)-producing islet cell tumors and one patient with pseudo-pp-producing tumors were examined. Their age range was 20 to 74 years. Clinical features included abdominal pain in four patients, weight loss in four patients, diarrhea in two patients, gastrointestinal bleeding in two patients, and jaundice in one patient. The range of the basal serum level of PP was 394 to 35,100 pg/mL. In two patients the PP-producing tumors were associated with multiple endocrine neoplasia. Two patients had diffuse hepatic metastases at the time of diagnosis and four patients had disease limited to the pancreas. Pancreaticoduodenectomy and 80% pancreatectomy were performed in four and two patients, respectively. Immunohistochemical staining was positive for PP and neuron-specific enolase in all cases and was negative for other peptides except in one specimen with microadenomatosis. Patients who underwent curative resection are asymptomatic with normal serum levels of PP.

(Arch Surg 1984;119:508-514)

Author Affiliations
From the Department of Surgery, Section of General Surgery (Drs Strodel, Eckhauser, Fiddian-Green, Turcotte, and Thompson), Department of Medicine, Division of Endocrinology and Metabolism (Drs Vinik and Glaser), and Department of Pathology (Dr Lloyd), University Hospital and Veterans Administration Medical Center, University of Michigan Medical Center, Ann Arbor.

Footnotes
Accepted for publication Jan 30, 1984.

Read before the 91st annual meeting of the Western Surgical Association, Monterey, Calif, Nov 16, 1983.

Reprint requests to D2220 SACB, University Hospital, Ann Arbor, MI 48109 (Dr Strodel).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Sonic hedgehog and pancreatic-duodenal homeobox 1 expression distinguish between duodenal and pancreatic gastrinomas
Fendrich et al.
Endocr Relat Cancer 2009;16:613-622.
ABSTRACT | FULL TEXT