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Malignant Potential

Arun K. Gosain, MD; Orlo H. Clark, MD

Arch Surg. 1984;119(5):515-519.

Abstract
• We studied the records of patients with Hürthle cell neoplasms seen at the University of California at San Francisco, from 1943 to 1982, because of controversy concerning the malignant potential of these tumors. Of our 84 patients, 71 had Hürthle cell adenomas (HCAs), nine had Hürthle cell change in chronic thyroiditis, and four had Hürthle cell carcinomas. Coexisting papillary thyroid carcinoma occurred in three patients with HCA. Twelve patients with HCAs had multiple lesions, five of which were bilateral. Patients with HCA were followed up for 675 patient-years, 45 for four years or more (maximum duration, 36 years). There were no recurrences or deaths among the patients with benign Hürthle cell tumors. Thus, patients with HCA had a benign course, and histologic examination results accurately reflected malignant potential.

(Arch Surg 1984;119:515-519)

Author Affiliations
From the Surgical Service, Veterans Administration Medical Center and the Department of Surgery, University of California, San Francisco.

Footnotes
Accepted for publication Jan 16, 1984.

Read before the 91st annual meeting of the Western Surgical Association, Monterey, Calif, Nov 14, 1983.

Reprint requests to Surgical Service (112), VA Medical Center, 4150 Clement St, San Francisco, CA 94121 (Dr Clark).

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