This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (35)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Clinical Management

Clive S. Grant, MD; Paul Carpenter, MD; Jon A. van Heerden, MB, FRCS(C); Bertil Hamberger, MD

Arch Surg. 1984;119(5):585-590.

Abstract
• We retrospectively reviewed the clinical features, methods of diagnosis and localization, and results of treatment in 105 patients with primary aldosteronism seen between 1969 and 1981. Coincident with the use of computed tomography (CT), ¹³¹I-6-β-iodomethyl norcholesterol scans (NP-59), and postural response studies, the study group was temporally divided into pre-1976 and post-1976 groups, and subdivided into groups with aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism (IHA) due to bilateral adrenal hyperplasia. Our results indicate that aldosterone postural response studies and CT differentiate and localize APA and IHA reliably. Adrenalectomy is a safe and effective treatment for APA, whereas medical treatment alone is preferable for IHA.

(Arch Surg 1984;119:585-590)

Author Affiliations
From the Departments of Surgery (Drs Grant and van Heerden) and Internal Medicine (Dr Carpenter), Mayo Clinic and Mayo Foundation, Rochester, Minn; and the Department of Surgery, Karolinska Hospital, Stockholm (Dr Hamberger).

Footnotes
Accepted for publication Jan 5, 1984.

Read before the 91st annual meeting of the Western Surgical Association, Monterey, Calif, Nov 14, 1983.

Reprint requests to Mayo Clinic, 200 First St SW, Rochester, MN 55905 (Dr Grant).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Small tumor size as favorable prognostic factor after adrenalectomy in Conn's adenoma
Giacchetti et al.
Eur J Endocrinol 2009;160:639-646.
ABSTRACT | FULL TEXT  

Aldosterone-producing adrenocortical carcinoma: an unusual cause of Conn's syndrome with an ominous clinical course
Seccia et al.
Endocr Relat Cancer 2005;12:149-159.
ABSTRACT | FULL TEXT  

Trends in the prevalence of primary aldosteronism, aldosterone-producing adenomas, and surgically correctable aldosterone-dependent hypertension
Plouin et al.
Nephrol Dial Transplant 2004;19:774-777.
FULL TEXT  

Functioning adrenal pathology
Rockall and Sahdev
Imaging 2002;14:122-136.
ABSTRACT | FULL TEXT  

Factors Influencing Outcome of Surgery for Primary Aldosteronism
Celen et al.
Arch Surg 1996;131:646-650.
ABSTRACT