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Cyrus A. Kotwall, MD; Alexander S. Clanachan, PhD; Hans P. Baer, PhD; Gerald W. Scott, MB, FRCS(C)

Arch Surg. 1984;119(6):709-712.

Abstract
• Prostaglandins (PGs) affect smooth-muscle contractility and are also involved in the inflammatory reaction. They may therefore affect gallbladder motility in cholecystitis. The contractile effects of PGs were recorded in organ baths on strips from 63 fresh, surgically removed human gallbladders. Spontaneous rhythmic contractions were reduced or abolished by indomethacin, which inhibits endogenous PG synthesis. In strips with chronic cholecystitis, concentration-dependent contractions were produced by PGF₂, PGB₂ and PGD₂; the responses to PGE₁ and PGE₂ were sometimes variable but there were concentration-dependent contractions after treatment of the strips with indomethacin. The majority of strips with acute cholecystitis responded poorly to PGs even after pretreatment with indomethacin. We concluded from this preliminary study that PGs could affect gallbladder motility and that indomethacin probably reduces the endogenous production of PGs in the gallbladder.

(Arch Surg 1984;119:709-712)

Author Affiliations
From the Biliary Research Group, Departments of Surgery (Drs Kotwall and Scott) and Pharmacology (Drs Clanachan and Baer), University of Alberta, Edmonton.

Footnotes
Accepted for publication Jan 30, 1984.

Read before the 91st annual meeting of the Western Surgical Association, Monterey, Calif, Nov 16, 1983.

Reprint requests to Surgical-Medical Research Institute, University of Alberta, Edmonton, Alberta, Canada T6G 2N8 (Dr Scott).

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