This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (73)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Anatomic Considerations, Operative Technique, and Treatment Morbidity

John M. Daly, MD; Nancy Kemeny, MD; Paula Oderman, RN; Jose Botet, MD

Arch Surg. 1984;119(8):936-941.

Abstract
• Disappointment with the results of systemic chemotherapy for treatment of colorectal hepatic metastases has led to renewed interest in hepatic arterial infusion chemotherapy. Forty adult patients underwent preoperative examination, operative staging of the extent of liver involvement, and surgical placement of an implantable pump with the catheter in the hepatic arterial system. Twenty-one patients were previously untreated. Hepatic involvement ranged from 15% to 85%; none of the patients had unresectable extrahepatic disease. Operative complications occurred in 10% of the patients; there were no deaths. Treatment morbidity consisted of gastrointestinal tract inflammation and/or ulceration (48%) and hepatitis (65%). Partial tumor responses occurred in nine of 18 previously untreated patients and five of 16 previously treated patients. Use of an implantable pump for long-term hepatic arterial chemotherapy was associated with improved patient acceptance, minimal operative morbidity, and substantial tumor response to chemotherapy.

(Arch Surg 1984;119:936-941)

Author Affiliations
From the Departments of Surgery (Dr Daly), Medicine (Dr Kemeny), Nursing (Ms Oderman), and Radiology (Dr Botet), Memorial Sloan-Kettering Cancer Center, New York.

Footnotes
Accepted for publication Jan 19, 1984.

Reprint requests to Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021 (Dr Daly).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Hepatic Arterial Infusion Versus Systemic Therapy for Hepatic Metastases From Colorectal Cancer: A Randomized Trial of Efficacy, Quality of Life, and Molecular Markers (CALGB 9481)
Kemeny et al.
JCO 2006;24:1395-1403.
ABSTRACT | FULL TEXT  

Multidetector CT Arteriography with Volumetric Three-Dimensional Rendering to Evaluate Patients with Metastatic Colorectal Disease for Placement of a Floxuridine Infusion Pump
Kapoor et al.
Am. J. Roentgenol. 2003;181:455-463.
ABSTRACT | FULL TEXT  

Alternating Hepatic Arterial Infusion and Systemic Chemotherapy for Liver Metastases From Colorectal Cancer: A Phase II Trial Using Intermittent Percutaneous Hepatic Arterial Access
Copur et al.
JCO 2001;19:2404-2412.
ABSTRACT | FULL TEXT  

Patency Rate of Implantable Devices During Long-Term Intraaterial Chemotherapy
Huk et al.
ANGIOLOGY 1990;41:936-941.
ABSTRACT  

Regional Infusion for Colorectal Hepatic Metastases: A Randomized Trial Comparing the Hepatic Artery With the Portal Vein
Daly et al.
Arch Surg 1987;122:1273-1277.
ABSTRACT  

The Use of the Implantable Chemoinfusion Pump in the Treatment of Hepatic Metastases of Colorectal Cancer
Ramming and O'Toole
Arch Surg 1986;121:1440-1444.
ABSTRACT