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Thomas P. Barragry, MD; Mark R. Wick, MD; John P. Delaney, MD

Arch Surg. 1985;120(10):1178-1181.

Abstract
• The case history of a patient with an islet cell carcinoma, which produced both gastrin and vasoactive intestinal polypeptide (VIP), is presented. Although several examples have been observed of the combined production of these hormones by pancreatic endocrine tumors, few reports have related the clinical details of such cases. Resolution of diarrhea occurred in our patient after institution of nasogastric suction and cimetidine therapy, suggesting that gastric hypersecretion, rather than VIP activity, accounted for this problem. Chemotherapy with streptozotocin and 5-fluorouracil was highly effective in ameliorating clinical symptoms, diminishing serum levels of gastrin and VIP, and greatly reducing the bulk of metastatic disease in this case.

(Arch Surg 1985;120:1178-1181)

Author Affiliations
From the Departments of Surgery (Drs Barragry and Delaney) and Laboratory Medicine and Pathology (Dr Wick), University of Minnesota School of Medicine, Minneapolis.

Footnotes
Accepted for publication June 21, 1985.

Reprint requests to Box 35, Mayo Memorial Building, University of Minnesota Hospitals, 516 Delaware St SE, Minneapolis, MN 55455 (Dr Barragry).

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