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Mark A. Malangoni, MD; Lillian G. Dawes, MD; Elizabeth A. Droege, MD; Shyam A. Rao, PhD; B. David Collier, MD; Urias A. Almagro, MD

Arch Surg. 1985;120(3):275-278.

Abstract
• We investigated splenic reticuloendothelial activity after splenic preservation procedures to determine their effect upon the phagocytic function of the spleen. We performed the following procedures in Sprague-Dawley rats: sham laparotomy, total splenectomy, hemisplenectomy, subtotal splenectomy, or total splenectomy with intraperitoneal splenic autotransplantation. At nine weeks after operation, phagocytic function of the spleen was determined by measuring radiocolloid uptake. Mean (±SEM) splenic phagocytic indices for sham laparotomy (41.2±2.9), hemisplenectomy (44±2.9), and subtotal splenectomy (43.2±5.2) were similar; however, the phagocytic index was reduced markedly after autotransplantation (15.8 ± 2.2). These data demonstrate that the phagocytic function of the spleen after hemisplenectomy and subtotal splenectomy correlates highly with the weight of the splenic remnant; however, phagocytic function after autotransplantation remains reduced even after accounting for differences in splenic weight.

(Arch Surg 1985;120:275-278)

Author Affiliations
From the Department of Surgery, University of Louisville (Dr Malangoni); the Departments of Surgery (Drs Dawes and Droege), Radiology (Drs Rao and Collier), and Pathology (Dr Almagro), Medical College of Wisconsin, Milwaukee; and the Surgical (Drs Malangoni, Dawes, and Droege) and Pathology (Dr Almagro) Services, Wood Veterans Administration Medical Center, Milwaukee.

Footnotes
Accepted for publication Sept 18, 1984.

Read before the Eighth Annual Surgical Symposium of the Association of Veterans Administration Surgeons, Los Angeles, May 10, 1984.

Reprint requests to Department of Surgery, University of Louisville, Louisville, KY 40292 (Dr Malangoni).

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ABSTRACT