Experimental Myocardial Ischemia: Differential Injury of Mitochondrial Subpopulations

doi:10.1001/archsurg.1985.01390270070012

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Vol. 120 No. 3, March 1985

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PAPERS READ BEFORE THE EIGHTH ANNUAL SURGICAL SYMPOSIUM OF THE ASSOCIATION OF VETERANS ADMINISTRATION SURGEONS, LOS ANGELES, MAY 9-12, 1984

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Experimental Myocardial Ischemia

Differential Injury of Mitochondrial Subpopulations

Eric S. Weinstein, MD; Daniel W. Benson; Deborah J. Ratcliffe, MS; John Maksem, MD; Donald E. Fry, MD

Arch Surg. 1985;120(3):332-338.

Abstract

• Distinct populations of subsarcolemmal (SS) and interfibrillar(IF) rat cardiac mitochondria were studied following 15 and30 minutes of warm and cold global ischemia. The respiratorycontrol index, state 3, state 4, adenosine diphosphate—oxygenratio, and specific enzyme activities of these mitochondrialpopulations were examined. The subsarcolemmar and IF mitochondriawere both severely uncoupled and inhibited by warm ischemia.However, IF mitochondria had a higher RCI at each ischemic interval.In cold ischemia, IF mitochondria were not injured comparedwith control specimens. Subsarcolemmar mitochondria showed atrend towards a lower RCI that was statistically significantat 30 minutes with succinate as a substrate. These data implicatea differential injury of ischemia on the compartmentalized bioenergymetabolism of the myocardial cell.

(Arch Surg 1985;120:332-338)

Author Affiliations

From the Department of Surgery (Drs Weinstein and Fry, Mr Benson, and Ms Ratcliffe) and Pathology (Dr Maksem), Veterans Administration Medical Center, Cleveland; and the Department of Surgery, Case Western Reserve University, Cleveland (Drs Weinstein and Fry, Mr Benson, and Ms Ratcliffe). Dr Weinstein is a Dudley P. Allen Research Fellow for the Department of General Surgery at Case Western Reserve University Hospitals.

Footnotes

Accepted for publication Aug 29, 1984.

Read before the Eighth Annual Surgical Symposium of the Associationof Veterans Administration Surgeons, Los Angeles, May 11, 1984.

Reprint requests to Chief, Surgical Service (112W), VA MedicalCenter, 10701 East Blvd, Cleveland, OH 44106 (Dr Fry).

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