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Effects of Methylprednisolone on Its Development

Ingvar Jansson, MD, PhD; Björn Bäckstrand, MD; Lennart Rammer, MD, PhD; Sten Lennquist, MD, PhD

Arch Surg. 1985;120(4):453-458.

Abstract
• The effects of methylprednisolone sodium succinate on the course of posttraumatic pulmonary microembolism were studied in pigs submitted to a reproducible high-energy trauma of the limb and then observed under long-term anesthesia. Methylprednisolone sodium succinate (30 mg/kg of body weight) was given one hour after trauma and thereafter every eighth hour during a 72-hour observation period. Intrapulmonary microembolism was quantitatively measured by repeated external detection of chromium 51–labeled platelets and iodine 125–labeled fibrinogen, sequential chest roentgenograms, and morphologic examination of the lungs post mortem. Methylprednisolone delayed the onset of pulmonary roentgenogram changes and modulated Pao₂ and platelet count reductions, but, at the end of the observation period, the signs of microembolism changes were as pronounced as in the nontreated traumatized pigs. Methylprednisolone thus did not prevent posttraumatic pulmonary microembolism in this experimental situation.

(Arch Surg 1985;120:453-458)

Author Affiliations
From the Department of General Surgery (Drs Jansson, Bäckstrand, and Lennquist), and the State Institute of Forensic Medicine (Dr Rammer), Clinical Research Center, University Hospital, Linköping, Sweden.

Footnotes
Accepted for publication Oct 18, 1984.

Reprint requests to Department of General Surgery, University Hospital, S-58185 Linköping, Sweden (Dr Jansson).

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