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Demetrius H. Bagley, MD; Lawrence S. Zachary, MD; Martin C. Robson, MD; John Heggers, PhD

Arch Surg. 1985;120(6):752-753.

Abstract
• The concentration of cefoxitin was determined in fluid obtained from human surgical wounds during the first post-operative day. Intravenous administration of cefoxitin sodium at a dosage of 1 or 2 g every six hours rapidly produced wound-fluid concentrations greater than the minimal inhibitory concentration for most susceptible organisms. After three hours, wound-fluid concentrations surpassed the serum concentrations of cefoxitin. The higher dosage resulted in higher wound-fluid levels.

(Arch Surg 1985;120:752-753)

Author Affiliations
From the Department of Urology, Thomas Jefferson University, Philadelphia (Dr Bagley), and the Department of Surgery, Division of Plastic and Reconstructive Surgery, Wayne State University Medical Center, Detroit (Drs Zachary, Robson, and Heggers).

Footnotes
Accepted for publication Aug 17, 1984.

Reprint requests to Department of Urology, Jefferson Medical College, 1025 Walnut St, Philadelphia, PA 19107 (Dr Bagley).

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