This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

E. Stan Lennard, MD, ScD; Barbara H. Minshew, PhD; E. Patchen Dellinger, MD; Margaret J. Wertz, MN, RN; David M. Heimbach, MD; George W. Counts, MD; Fritz D. Schoenknecht, MD; Marie B. Coyle, PhD

Arch Surg. 1985;120(8):889-898.

Abstract
• A randomized, prospective trial was conducted of 93 patients with operatively confirmed intra-abdominal sepsis. The study compared clindamycin-gentamicin and chloramphenicol-gentamicin for treatment of carefully stratified patient groups. Malnutrition, age over 65 years, shock, alcoholism, gastrointestinal tract bleeding, steroid administration, diabetes, obesity, and organ malfunction were present with equal frequencies in each group. The duration of antibiotic treatment averaged 8 days, and the average length of postoperative hospitalization was 29 days. Study antibiotics were changed for bacteriologic reasons in 11 patients taking clindamycin-gentamicin and 12 patients taking chloramphenicol-gentamicin (25% of the total), and two patients in the clindamycin-gentamicin group had a minor adverse reaction. Initial satisfactory clinical responses were obtained in 59 (63%) patients. Twenty-five patients (27%) subsequently developed unsatisfactory courses, but 48 (52%) patients remained well through the 30-day period. Septic-related mortality occurred in 18 (19%) patients, and two (2%) patients had unrelated deaths. There were no significant differences between the study regimens by the outcome criteria evaluated.

(Arch Surg 1985;120:889-898)

Author Affiliations
From the Departments of Surgery (Drs Lennard, Dellinger, and Heimbach and Ms Wertz), Medicine (Dr Counts), Laboratory Medicine (Drs Minshew, Schoenknecht, and Coyle), and Microbiology and Immunology (Dr Schoenknecht), University of Washington School of Medicine, Seattle.

Footnotes
Accepted for publication Jan 15, 1985.

Presented in part at the 21st Interscience Conference on Antimicrobial Agents and Chemotherapy, Las Vegas, Nov 4, 1981.

Reprint requests to Department of Surgery, University Hospital RF-25, Seattle, WA 98195 (Dr Lennard).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Reoperative Surgery for Periampullary Adenocarcinoma
McGuire et al.
Arch Surg 1991;126:1205-1212.
ABSTRACT