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A Prospectively Randomized Trial

Reinhart Grundmann, MD; Sigrid Heistermann

Arch Surg. 1985;120(8):911-915.

Abstract
• In a prospectively randomized trial of 220 patients, 106 were given albumin when their colloid osmotic pressure (COP) fell below 24 cm H₂O and 114 were given albumin when their COP fell below 29 cm H₂O. There was no difference in the postoperative course between the two groups; however, by using the lower COP limit the postoperative albumin consumption in the intensive care unit was reduced significantly and thus the costs of treatment were lowered. In the case of extremely low COP, the prognosis of the disease worsened, indicating that the COP is of prognostic value. The albumin supply, however, did not influence the final outcome of the patients under these circumstances because it treated only a characteristic symptom and not the cause of the disease.

(Arch Surg 1985;120:911-915)

Author Affiliations
From the Chirurgische Universitätsklinik Köln-Lindenthal, Köln, West Germany.

Footnotes
Accepted for publication Nov 6, 1984.

Reprint requests to Chirurgische Universitätsklinik Köln-Lindenthal, Joseph-Stelzmann-Str 9, D-5000 Köln 41, West Germany (Prof Dr Grundmann).

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