Decreased Hepatic Glutathione Levels in Septic Shock: Predisposition of Hepatocytes to Oxidative Stress: An Experimental Approach

doi:10.1001/archsurg.1985.01390320065013

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Vol. 120 No. 8, August 1985

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Decreased Hepatic Glutathione Levels in Septic Shock

Predisposition of Hepatocytes to Oxidative Stress: An Experimental Approach

Gary A. Keller, MD; Roderick Barke, MD; John T. Harty; Edward Humphrey, MD, PhD; Richard L. Simmons, MD

Arch Surg. 1985;120(8):941-945.

Abstract

• Intracellular metabolite glutathione, existing in eitherits reduced (GSH) or oxidized states, is crucial for the protectionof any cell against an oxidative stress or injury. Significantdepletion of intracellular levels of GSH predisposes cells toan oxidative injury. We have investigated the level of hepaticGSH during the early course of sepsis in a physiologically well-characterizedseptic-sheep model. Following six hours of sepsis, which wascharacterized by hypotension, hypoxemia, and granulocytopenia,the level of intrahepatic GSH was significantly reduced comparedwith baseline levels. There was no reduction after two hoursof sepsis. Hepatic GSH levels in control animals were unchangedcompared with baseline levels. These findings suggest that theliver may be more susceptible to an oxidative stress in septicpatients.

(Arch Surg 1985;120:941-945)

Author Affiliations

From the Division of Surgical Infectious Diseases, Department of Surgery, University of Minnesota (Drs Keller and Simmons and Mr Harty); and the Veterans Administration Medical Center, Minneapolis (Drs Barke and Humphrey).

Footnotes

Accepted for publication Jan 14, 1985.

Reprints not available.

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