This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Histological and Ultrastructural Studies

A. Hope McArdle, PhD; Carin Wittnich, DVM; Carolyn R. Freeman, MB, BS; William P. Duguid, MD

Arch Surg. 1985;120(9):1026-1032.

Abstract
• We investigated whether elemental diet feeding would protect the intestine from radiation injury. Five dogs were fed an elemental diet for three days before receiving pelvic irradiation (500 rad/day for four days) and were maintained on the diet during the days of irradiation. These dogs were compared with five dogs that were fed normal kennel ration, but were treated similarly otherwise. One day and five days following completion of the radiation treatment, the dogs were anesthetized and a biopsy specimen of terminal ileum was taken for histologic and electron microscopic studies. In the dogs fed the elemental diet, there was no significant damage to the intestine seen on histological examination, and electron microscopy disclosed elongated microvilli and no organelle damage. However, both histological and electron microscopic examination of the intestine from dogs maintained on normal kennel ration showed that severe damage had occurred from the irradiation procedure. It seems, therefore, that the feeding of an elemental diet to dogs as a prophylaxis can afford protection to the intestine from the acute phase of radiation injury.

(Arch Surg 1985;120:1026-1032)

Author Affiliations
From the Departments of Surgery (Drs McArdle and Wittnich), Radiation Oncology (Dr Freeman), and Pathology (Dr Duguid), The Montreal General Hospital.

Footnotes
Accepted for publication Jan 14, 1985.

Reprint requests to Room 947, The Montreal General Hospital, 1650 Cedar Ave, Montreal, Quebec, Canada H3G 1A4 (Dr McArdle).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Whey protein potentiates the intestinotrophic action of glucagon-like peptide-2 in parenterally fed rats
Liu et al.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009;297:R1554-R1562.
ABSTRACT | FULL TEXT  

Synergistic effect of supplemental enteral nutrients and exogenous glucagon-like peptide 2 on intestinal adaptation in a rat model of short bowel syndrome.
Liu et al.
Am. J. Clin. Nutr. 2006;84:1142-1150.
ABSTRACT | FULL TEXT  

Prophylaxis Against Radiation Injury: The Use of Elemental Diet Prior to and During Radiotherapy for Invasive Bladder Cancer and in Early Postoperative Feeding Following Radical Cystectomy and Heal Conduit
McArdle et al.
Arch Surg 1986;121:879-885.
ABSTRACT